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PHARMACEUTICAL COMPOSITION
专利权人:
Ферринг Б.В. (NL)
发明人:
НИЛЬССОН Андерс (DK),МАЛЬМ Маттиас (DK),ВИСНЕВСКИ Казимеж (US),СИКМАНН Бритта (SE)
申请号:
RU2013112666/15
公开号:
RU2013112666A
申请日:
2011.09.29
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A liquid composition containing carbetocin or a pharmaceutically active salt thereof, wherein the pH of the composition is from 5.0 to 6.0.2. The composition according to claim 1, which is an aqueous composition. The composition according to claim 1, where the pH of the composition is from 5.1 to 6.0.4. The composition according to claim 1, where the pH value of the composition is from 5.2 to 5.65.5. The composition according to claim 1, where the pH value of the composition is from 5.26 to 5.8.6. The composition according to claim 1, containing a buffering agent. The composition of claim 6, wherein the buffering agent is succinic acid. The composition according to claim 1, containing a buffer. The composition of claim 8, wherein the buffer is a succinate or citrate phosphate buffer. The composition of claim 6, wherein only one buffer or buffer agent is present. The composition according to claim 1, where the concentration of carbetocin is from 0.01 to 55 mg / ml, for example from 0.01 to 10 mg / ml, for example from 0.01 to 1.5 mg / ml. The composition of claim 1, further comprising an antioxidant. The composition of claim 12, wherein the antioxidant is methionine, ethylenediaminetetraacetic acid (EDTA), or a combination of methionine and EDTA. The composition of claim 1, further comprising an agent for maintaining isotonicity. A liquid (eg, aqueous) composition comprising: a pharmaceutically active compound or a salt thereof and an antioxidant, wherein the pH of the composition is from 5.0 to 6.0.16. The composition of claim 15, wherein the pH is from 5.1 to 6, for example from 5.2 to 5.65, or from 5.26 to 5.8.17. The composition of claim 15, wherein the pharmaceutical compound is selected from: carbetocin; the compounds of formula (I): wherein: n is selected from 0, 1, and 2; p is selected from 0, 1, 2, 3, 4, 5, and 6; R is selected from aryl, optionally substituted with at least one substituent, which is OH, F, Cl, Br, alkyl or O-alkyl1. Жидкая композиция, со
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