FONDAZIONE RI.MED;ISTITUTO MEDITERRANEO PER I TRAPIANTI E TERAPIE AD ALTA SPECIALIZZAZIONE S.R.L. - I.S.M.E.T.T. S.R.L.
发明人:
PASTA, Salvatore,SCARDULLA, Cesare
申请号：
WO2018IB53882
公开号：
WO2018220573(A1)
申请日:
2018.05.31
申请国别(地区):
世界知识产权组织国际局
年份:
2018
代理人:
摘要：
A method for calculating the risk of aortic rupture or dissection of an individual with an ascending thoracic aortic aneurysm, ATAA, comprising the steps of obtaining (10) a first data set (12) linked to the clinical and/or demographic characteristics of the individual, obtaining (20) a second data set (22) linked to the biochemical characteristics of a biological sample of the individual, obtaining (30) a third data set (32) linked to the morphological and functional characteristics of the aorta and processing said third data set (32) to obtain (40) a fourth data set (42) by computational modelling, integrating the first data set (12), the second data set (22), the third data set (32) and the fourth data set (42) in a predictive model to obtain a risk index (i) of aortic rupture or dissection, wherein the second data set (22) comprises expression values of at least one biomarker.
