Roger Adami,Yuwei Wang,Haiqing Yin,Liping Wang,Dong Liu,Wenbin Ying
申请号：
US16377032
公开号：
US20190231695A1
申请日:
2019.04.05
申请国别(地区):
US
年份:
2019
代理人:
摘要：
This invention provides compositions for making a solid lyophile of one or more nucleic acid active agents, which can be reconstituted as a drug product. The composition can include an aqueous suspension of lipid nanoparticles in a pharmaceutically acceptable solution, wherein the lipid nanoparticles encapsulate one or more nucleic acid active agents, a dextrin compound, and a saccharide compound. The nucleic acid active agents can be RNAi molecules capable of mediating RNA interference, as well as other RNAs and oligonucleotides.
