Various embodiments provide compositions for a hair loss treatment composition for promoting hair growth and/or hair thickness and methods for their manufacture. In various exemplary embodiments, the active agent may comprise a preparation of a steroid, a steroid precursor, an estrogen biomimetic, serotonin agonist, and/or an amino acid. In various embodiments, the active agent may comprise a preparation of at least part of a whole plant, a crude plant extract, an at least partially refined plant extract, and a derivative of the plant extract. Exemplary methods for producing the active agent may comprise combining effective amounts of the components of the active agent. The active agent may be for topical use and may be formulated for delivery to at least one of: a hair follicle, a hair follicle shaft, and skin surrounding the hair follicle.
