CRYSTALLINE FORMS OF ALISKIREN HEMIFUMARATE N-(3-amino-2,2-dimethyl-3-oxopropyl)-2,7-di(1-methylethyl)-4-hydroxy-5-amino-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]-octanamide

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专利权人:

NOVARTIS AG

发明人:

STOWASSER, FRANK,MONNIER, STEPHANIE

申请号：

NZ57732007

公开号：

NZ577320A

申请日:

2007.11.05

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Disclosed is a crystal form of aliskiren hemifumarate, systematic name 2(S),4(S),5(S),7(S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-2,7-di(1-methylethyl)-4-hydroxy-5-amino-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]-octanamide, characterized by an X-Ray powder diffraction pattern showing the following main peaks given at degrees 2Theta plus or minus 0.3 degrees: 3.8, 6.5, 7.7, 8.0, 15.6 and 17.4. The crystalline form is suitable for use in the treatment of a disease which can be modulated by blocking the AT1 receptor.

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