It does not possess the danger like the sodium hypochlorite aqueous solution, the Calicivirus of the lime wash virus and the like which at the same time is included in the suffering out poison, under coexisting of the organic matter which designates the protein as the main component, effectively deactivation conversion or non- to life it offers the manner which can be converted. Ethanol and the Acid are included in those where existence of the Calicivirus is doubted, at the same time contains the protein, as a active ingredient, the fact that the constituent which consists of the aqueous solution where pH are 2.5 - 5.0 ranges is made to contact is included, the manner which the Calicivirus under protein coexisting non- to life is converted. As for the aforementioned Calicivirus, for example, it is the lime wash virus.次亜塩素酸ナトリウム水溶液のような危険性を有さず、かつ被消毒物に含まれるノロウイルス等のカリシウイルスを、タンパク質を主成分とする有機物の共存下であっても有効に失活化または不活化できる方法を提供する。カリシウイルスの存在が疑われ、かつタンパク質を含有する物に、有効成分としてエタノールと酸を含み、pHが2.5~5.0の範囲にある水溶液からなる組成物を接触させることを含む、タンパク質共存下のカリシウイルスを不活化する方法。前記カリシウイルスは、例えば、ノロウイルスである。
