Ayer, Atul D.,Guinta, Diane R.,Hamel, Lawrence G.,Hatamkhany, Zahedeh,Lam, Andrew C.,Saks, Samuel R.,Shivanand, Padmaja,Weyers, Richard G.,Wright, Jeri D.,Christopher, Carol A.,Gupta, Suneel K.
申请号：
AU2010249205
公开号：
AU2010249205B2
申请日:
2010.12.07
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2010249205B220120628.pdf#####ABSTRACT Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended timc period are provided. The dosage forms may additionally comprise an immediate-release dose of drug. Fig. 22 12 5.000 4.500 4.000 3.500 RELEASE 3.000 RATE 2500 (mglhr) 2.000 1.500 1,0001 0.500 0.000 0 i 2 3 4 5 6 7 8 9 10 11 12 TIME (hrs) FIG. 3 96.. -- -------- -141 METHYLPHENIDATE CONCENTRATION .( n g l m L ) 3 ( O1' 0 0 2 4 6 8 10 12 TIME (h) FIG. 4
