An ultrasonic medicine paste for transdermally permeating a medicine to a body and the manufacture method thereof. The medicine paste includes an adhesive layer (1) as the base layer, a medicine layer (2) adjacent to the adhesive layer (1), and ultrasonic transducer (3) for generating ultrasonic signal, a driving unit (4) that supplies an electric signal and drives the ultrasonic transducer (3) to generate ultrasonic signal, and a coating layer (5) that covers the exterior surface thereof.
