SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH OPTIMIZED FUNCTIONAL CRISPR-CAS SYSTEMS

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专利权人:

President and Fellows of Harvard College;The Broad Institute Inc.;Massachusetts Institute of Technology;University of Tokyo

发明人:

Silvana Konermann,Alexandro Trevino,Mark Brigham,Fei Ran,Patrick Hsu,Chie-yu Lin,Osamu Nureki,Hiroshi Nishimasu,Ryuichiro Ishitani,Feng Zhang

申请号：

US15179912

公开号：

US20160355797A1

申请日:

2016.06.10

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/