USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I.;USTAV MAKROMOLEKULARNI CHEMIE AV CR;MIKROBIOLOGICKY USTAV AV CR, V.V.I.; V.V.I.
发明人:
ETRYCH, TOMAS,CHYTIL, PETR,STROHALM, JIRI,ULBRICH, KAREL,RIHOVA, BLANKA
申请号：
CA2783393
公开号：
CA2783393C
申请日:
2010.12.14
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention relates to water-soluble high-molecular-weight polymer drug carriers and their conjugates with drugs, derived from dendrimers of the amidoamine and 2,2-bis(hydroxymethyl)propanoic types, the amino and hydroxy end groups of which are attached to semitelechelic copolymers of N-(2 hydroxypropyl)methacrylamide (HPMA) through biodegradable spacers. The polymer carriers and conjugates enable targeted transport notably of anticancer drugs into solid tumors in which biodegradation, the associated controlled drug release and subsequent elimination of polymer carrier from the organism are provided. The polymer carrier conjugated with a cancerostatic for use in targeted therapy of human tumors.
