BISPECIFIC BINDING MOLECULES FOR ANTI-ANGIOGENESIS THERAPY

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专利权人:

BOEHRINGER INGELHEIM INTERNATIONAL GMBH

发明人:

BORGES, Eric,GSCHWIND, Andreas,BOUCNEAU, Joachim,DE TAVERNIER, Evelyn,KOLKMAN, Joost,MERCHIERS, Pascal,VAN HOORICK, Diane

申请号：

TN2012000145

公开号：

TN2012000145A1

申请日:

2012.03.29

申请国别(地区):

TN

年份:

2013

代理人:

摘要：

Bispecific binding molecules, in particular immunoglobulin single variable domains such as VHHs and domain antibodies, comprising a VEGF-binding component and a Dll4-binding component in one molecule. Pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with VEGF- and Dll4-mediated effects on angiogenesis. Nucleic acids encoding the bispecific binding molecules, host cells and methods for preparing same.

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