Javier CORTÉS CASTÁN;Violeta SERRA ELIZALDE;Alejandro PIRIS GIMÉNEZ
发明人:
Javier Cortés Castán,Alejandro Piris Giménez,Violeta Serra Elizalde
申请号：
US14895111
公开号：
US20160120871A1
申请日:
2014.06.10
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to a combination comprising (a) a phosphatidylinositol 3-kinase inhibitor selected from 5-(2,6-di-morpholin-4-yl-pyrimidin-4-yl)-4-trifluoromethyl-pyridin-2-ylamine, (S)-Pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide) or a pharmaceutically acceptable salts thereof, and (b) a microtubule destabilizing agent for simultaneous, separate or sequential use for the treatment of a tumor disease； a pharmaceutical composition comprising such combination； a method of treating a subject having a tumor disease comprising administration of said combination to a subject in need thereof； use of such combination for preparation of a medicament for the treatment of a tumor disease； and a commercial package thereto.
