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IMPROVED RECONSTITUTED SURFACTANT COMPOSITION CONTAINING ANALOGS OF SURFACTANT PROTEIN B (SP-B) AND SURFACTANT PROTEIN C (SP-C)
专利权人:
CHIESI FARMACEUTICI S.P.A.
发明人:
PIVETTI, FAUSTO,BOCCHI, MONICA,SOLIANI RASCHINI, ANNAMARIA
申请号:
NZ59684810
公开号:
NZ596848A
申请日:
2010.05.31
申请国别(地区):
NZ
年份:
2013
代理人:
摘要:
596848 IMPROVED RECONSTITUTED SURFACTANT COMPOSITION CONTAINING ANALOGS OF SURFACTANT PROTEIN B (SP-B) AND SURFACTANT PROTEIN C (SP-C) Provided is a reconstituted surfactant composition comprising: a) from 1.2 to 1.8% by weight of a functional fragment of the native surfactant protein SP-C consisting of the sequence represented by the formula IPSSPVHLKRLKLLLLLLLLILLLILGALLLGL; b) from 0.1 to 0.5% by weight of a functional fragment of the native surfactant protein SP-B consisting of the sequence represented by the formula CWLCRALIKRIQALIPKGGRLLPQLVCRLVLRCS; c) a monounsaturated and a saturated phospholipid in a weight ratio ranging from 45:55 to 55:45 wherein said monounsaturated phospholipid is selected from the group consisting of palmitoyloleoylphosphatidylcholine (POPC) and palmitoyloleoylphosphatidylglycerol (POPG) and wherein said saturated phospholipid is selected from the group consisting of dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylglycerol (DPPG); all the amounts being calculated relative to the total weight of the reconstituted surfactant.
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