Edward Norbert Van Den Brink;Cornelis Adriaan De Kruif;Mark Throsby
发明人:
Edward Norbert Van Den Brink,Cornelis Adriaan De Kruif,Mark Throsby
申请号：
US12310812
公开号：
US08192927B2
申请日:
2007.09.06
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. The disclosure provides nucleic acid molecules encoding the antibodies, their sequences and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis and/or treatment of an influenza virus H5N1 infection. In a preferred embodiment, the antibodies provide cross-subtype protection in vivo, such that infections with H5, H2, H6, H9 and H1-based influenza subtypes can be prevented and/or treated.
