SPIROCYCLIC DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS

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专利权人:

发明人:

申请号：

HK11107831.5

公开号：

HK1153739A

申请日:

2011.07.28

申请国别(地区):

HK

年份:

2012

代理人:

摘要：

This invention is related to new histone deacetylase inhibitors according to the general formula (I) wherein: the dotted line is an optional additional bond n is zero or an integer from 1 to 4 R 1 is hydrogen C 1 -C 6 alkyl, optionally substituted by aryl or by heteroaryl (CO) R 3 (SO 2 ) R 4 aryl or heteroaryl R 2 is C 1 -C 6 alkyl, optionally substituted by aryl or by heteroaryl aryl heteroaryl or (CO) R 5 X is CH 2 , oxygen or N R 6 Y is a bond, CH R 7 or N R 8 Z is oxygen, C R 9 R 10 or C= R 11 and R 3 , R 4 , R 5 , R 6 , R 3 R 8 , R 9 , R 10 and R 11 are as further defined in the specification and pharmaceutical acceptable salts thereof.

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