#$%^&*AU2019272021A120191219.pdf#####ABSTRACT This invention relates to repeated administration of antigen- specific immunotherapeutics using protocols, or elements thereof, that do not induce immunosuppression. In some embodiments, the protocol has been previously shown not induce immunosuppression in a subject. See Fig. 2.WO 2014/197616 PCT/US2014/040938 2/4 pOVA im. pOVA i. +fMTX i.p. KLH+CpG S.C. 0 7 14 21 28 5000 I I 50000-- ns 4000- 40000_ Md19 Ln El d34 UU E d40 S3000- 09 30000.L2000 *i 200001 000-- 10000 X XFig. 2 C T TTl C 'TmPT Tmr C T TT7 T7 U' /T-')T Tl T' I/7