This invention concerns a method of inducing an elevated level of adenosine inan individual by administering to said individual an effective amount ofeither i) recombinant protein CD73 or ii) a cytokine or another factor-beingcapable of inducing endothelial CD73 expression, or a combination thereof.Furthermore, the invention concerns a method for prevention or treatment of adisease or disorder requiring or benefiting from the elevation of theadenosine level in an individual, such as inflammatory conditions.Furthermore, the invention concerns a method of up-regulating endothelial CD73expression in an individual by administering to said individual an effectiveamount of a cytokine or another factor being capable of inducing endothelialCD73 expression, and to a method for prevention or treatment of a disease ordisorder requiring or benefiting from up-regulating endothelial CD73expression.
