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Dissolved (s) - N - (5 - ((R) - 2 - (2,5-difluorophenyl) - pyridine-1-il) - pyridine-3-il-3-hydroxypyridine-1
专利权人:
LOXO ONCOLOGY; INC.
发明人:
REYNOLDS, Mark,SMITH, Steven A.
申请号:
PE2018001945
公开号:
PE20181888A1
申请日:
2017.04.04
申请国别(地区):
PE
年份:
2018
代理人:
摘要:
It refers to the dissolving formula containing (s) - N - (5 - ((R) - 2 - (2,5-difluorophenyl) - pyridine-1-il) - pyrazole (1,5-a) pyridine-3-il) - 3-hydroxypyridine-1-hydroxypyridine-1-hydroxymethylamine (I) and a dissolving agent, or the acceptable salt containing (I) formula, with the content between 0.5% and 7%. The crystal form of the compound (I) is characterized by its diffraction peaks of a18.4 + - 0.2, 20.7 + - 02, 23.1 + - 0.2 and 24.0 + - 0.2. In the treatment of pain, cancer, inflammation and other aspects, this dissolving formula is useful.Referido a una formulacion liquida que comprende (S)-N-(5-((R)-2-(2,5-difluorofenil)-pirrolidina-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida de formula (I) y un agente solubilizante; o una sal farmaceuticamente aceptable de la misma, en donde el compuesto de formula (I) se encuentra en una cantidad de entre 0.5% a 7%. La forma cristalina del compuesto (I) se caracteriza por tener picos de difraccion de XRPD 2(theta) grados a: 18.4 +- 0.2, 20.7 +- 02, 23.1 +- 0.2 y 24.0 +- 0.2. Dicha formulacion liquida es util en el tratamiento del dolor, cancer, inflamacion entre otras
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