Derek Jantz,Michael G. Nicholson,James Jefferson Smith
申请号：
US15666425
公开号：
US20180023065A1
申请日:
2017.08.01
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Targeted transcriptional effectors (transcription activators and transcription repressors) derived from meganucleases are described. Also described are nucleic acids encoding same, and methods of using same to regulate gene expression. The targeted transcriptional effectors can comprise (i) a meganuclease DNA-binding domain lacking endonuclease cleavage activity that binds to a target recognition site； and (ii) a transcription effector domain.
