INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM)
发明人:
NASSIF, XAVIER,TINSLEY, COLIN,ACHTMAN, MARK,RUELLE, JEAN-LOUIS,VINALS, CARLA,MERKER, PETRA
申请号：
EP09163902.1
公开号：
EP2138582B1
申请日:
1997.07.11
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
DNA (I) comprises all or part of the genes, with their reading frames, present in Neisseria meningitidis (Nm) but not in N. gonorrheae (Ng) or N. lactamica (Nl), except for the genes involved in biosynthesis of the capsule polysaccharide, frpA or C, opc, porA, rotamase, sequence IC1106, IgA protease, pillin, pilC, proteins which bind transferrin and opacity proteins. Also claimed are: (1) host cells (particularly bacteria or Nm) transformed by >= 1 (I) (2) RNA transcripts (II) of (I) (3) nucleic acid (III) antisense to (I) or (II) (4) polypeptides (IV) encoded by (I) or (II) (5) antibodies (Ab), mono- or poly-clonal, directed against an epitope of (IV) or their fragments (6) anti-antibodies (AAb) able to recognise Ab (7) Nm-specific DNA banks, and (8) method for preparing DNA banks from selected cells.
