SCHULTZ, MELANIE,BURGDORF, LARS, THORE,FINSINGER, DIRK,BLAUKAT, ANDREE,GREINER, HARTMUT,ESDAR, CHRISTINA
申请号：
EP06829158.2
公开号：
EP1966212B1
申请日:
2006.11.28
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
Fused-ring diazepinone compounds (I) and their salts, derivatives, solvates and stereoisomers (including mixtures in all proportions) are new. Fused-ring diazepinone compounds of formula (I) and their salts, derivatives, solvates and stereoisomers (including mixtures in all proportions) are new. R 1>；', R 1>；'', R 1>；''', R 1>；'''', R 3>；, R 4>；, R 5>；', R 5>；'' and R 5>；''' : hydrogen, A, R 6>；, Ar, OR 6>；, SR 6>；, OAr, SAr, NR 6>； 2, NHAr, hal, nitro, cyano, (CH 2) mCOOR 6>；, (CH 2) mCOOAr, (CH 2) mCONR 6>； 2, (CH 2) mCONAAr, COA, COR 6>；, COAr, S(O) mA, S(O) mAr, NACOA, NACOAr, NASO 2A, NASO 2Ar, SO 2NR 6>； 2, SO 2NAAr, M(CH 2) nNR 6>； 2, M(CH 2)NAR 6>；, M(CH 2) nNA 2, M(CH 2) n(R 6>；) n, M(CH 2) n-oxopiperazine, -oxomorpholine or -oxopyrrolidine, M(CH 2) nC(CH 3) n(CH 2) nNR 6>； 2, M(CH 2) nMR 6>； nSO mA, M(CH 2) nMR 6>； 2S(O) mMR 6>； 2, M(CH 2) nMR 6>； 2S(O) mAr, (CH 2) nM(R 6>；) nSO mA, (CH 2) nM(R 6>；) nSO mMR 6>； 2, (CH 2) nM(R 6>；) nSO mAr, M(CH 2) nSO mA, M(CH 2) nSO mNR 6>； nA, M(CH 2) nSO mAr, (CH 2) nSO mA, (CH 2) nSO mMR 6>； n or (CH 2) nSO mAr, where two adjacent R 1>； may together form a saturated or unsaturated 5-6 membered carbo- or hetero-cycle, optionally substituted by 1 or 2 M； R 2>；' and R 2>；'' : R 6>；； R 6>； : hydrogen, hal, cyano, amino, nitro, SO 2(sic), 1-4C alkyl (optionally with one CH 2 replaced by O or S atom and/or by NH, NA, CONH, NHCO or CH=CH and/or 1-4 H can be replaced by hal and one Me can be replaced by NH 2, NHR 7>；, NR 7>； 2, nitro or SO 2； R 7>； : Me or Et； n : 0-5； m : 0-2； A : 1-14C linear, branched or cyclic alkyl, optionally with one or two CH 2 replaced by O or S and/or by NH, CONH, NHCO, CO or CH=CH and/or 1-7 H can be replaced by hal and 1 or 2 Me replaced by R 6>；； Ar : mono- or di-nuclear homo- or hetero-cycle with 1-4 N, O and/or S and 5-10 basic atoms, optionally substituted 1-3 times by carbonyl, hal, A, hydroxy, OA, NH 2, NHA, NA 2,
