The present invention relates to the diagnosis, prognosis, progression, and treatment of Alzheimers disease. In particular, Alzheimers disease can be characterized by the differential expression of certain genes, including ASB9, BIK, C7orfl6, NDP, NLRP2, PLP1, SLC45A2, TBX2, TUBB4, ZNF300, ADM2, FLJ35024, MT2A, PTGS2, ABCC2, ECEL1, EGFL8, FSTL5, and SMOC1. The present invention also relates to systems and methods of analyzing Alzheimers disease, methods of screening for treatment agents for Alzheimers disease and kits for the analysis of Alzheimers disease.