Giving and/or the method of detecting those, use of the magnetic particle, and the magnetic particle is disclosed influence in the magnetic particle of the action territory. As for the aforementioned method, the step which introduces the magnetic particle into the action territory and, in order for magnetization of step and the magnetic particle which form the selective magnetic field which possesses the spatial pattern of the kind of intensity of magnetic field where the 2nd sub zone where 1st it possesses low intensity of magnetic field has the sub zone and a higher intensity of magnetic field is formed to the action territory to change locally, the signal which depends on the magnetization of the action territory which can produce effect the step which changes the spatial position of two sub zones of the action territory with the drive magnetic field and, with the change of spatial position of the 1st and 2nd sub zone is acquiredStep and, it includes, the magnetic particle has the core territory and the shell territory, the core territory includes the magnetic material, the magnetic material of the core territory relatively high saturation magnetization mainly is offered, as the material of the metal the shell territory includes the metallic oxide material or the precious metal material mainly.作用領域の磁性粒子に影響を与え及び/又はそれらを検出する方法、磁性粒子、及び磁性粒子の使用が開示される。前記方法は、磁性粒子を作用領域に導入するステップと、低い磁界強度を有する第1のサブゾーン及びより高い磁界強度を有する第2のサブゾーンが作用領域に形成されるような磁界強度の空間パターンを有する選択磁界を生成するステップと、磁性粒子の磁化が局所的に変化するように、駆動磁界によって作用領域の2つのサブゾーンの空間位置を変えるステップと、第1及び第2サブゾーンの空間位置の変化によって影響を与えられる作用領域の磁化に依存する信号を取得するステップと、を含み、磁性粒子は、コア領域及びシェル領域を有し、コア領域は、磁性材料を含み、コア領域の磁性材料は、比較的高い飽和磁化の主に金属の材料として提供され、シェル領域は、主に金属酸化物材料又は貴金属材料を含む。
