울산대학교 산학협력단;UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
发明人:
CHANG, Eun-Ju,장은주,LEE, Eun-Jin,이은진
申请号：
KRKR2016/008612
公开号：
WO2017/034173A1
申请日:
2016.08.04
申请国别(地区):
KR
年份:
2017
代理人:
摘要：
The present invention relates to a biomarker composition for diagnosing cancer metastasis, containing AWP1, the composition being usable as a clinical indicator for cancer metastasis by identifying a decrease in the expression of AWP1 in cancers that easily metastasize in comparison to cancers that have not metastasized. In addition, it is ascertained that cancer growth and metastasis are increased when the expression of AWP1, having used siRNA, is inhibited and that, when AWP1 is overexpressed, cancer metastasis is inhibited by reducing cancer growth and migration, and thus AWP1 can be used as a cancer metastasis inhibitor.L'invention concerne un composition de biomarqueur permettant de diagnostiquer des métastases cancéreuses contenant AWP1, la composition étant utilisable comme indicateur clinique de métastases cancéreuses par identification d'une diminution de l'expression de AWP1 dans des cancers facilement métastasés par comparaison à des cancers non métastasés. En outre, il est établi que la croissance tumorale et les métastases augmentent lorsque l'expression de AWP1, avec utilisation d'un ARNsi, est inhibée et que, lorsque AWP1 est surexprimé, la métastase cancéreuse est inhibée par réduction de la croissance cancéreuse et de la migration.본 발명은 AWP1을 포함하는 암 전이 진단용 바이오마커 조성물에 관한 것으로서, 전이되지 않은 암에 비해 전이가 잘 되는 암에서 AWP1의 발현이 감소함을 확인하여 암 전이에 대한 임상지표자로서 사용될 수 있다. 또한, siRNA를 사용한 AWP1 발현 억제시 암 생장과 전이가 증가함을 확인하였고, AWP1을 과발현시켰을 때 암 생장과 이동을 감소시켜 암 전이를 억제함을 확인하였기에 AWP1은 암 전이 억제제로 활용될 가능성이 있다.
