Methods of treating joint damage in a subject eligible for treatment are provided involving administering an antagonist that binds to a B-cell surface marker, such as CD20 antibody, to the subject in an amount effective to slow progression of the joint damage as measured by radiography. Further provided are articles of manufacture useful for such methods.本發明提供一種治療適於治療受治者之關節損傷的方法，其涉及將與B細胞表面標記結合的拮抗劑諸如CD20抗體，以可有效減緩關節損傷進程之量投予至該受治者，其中該關節損傷程度係由放射線照相法來量測。本發明進一步提供適用於該等方法之製品。
