PROBLEM TO BE SOLVED: To provide an antitumor agent using an HSP90 inhibitor targeting heat shock protein HSP90 involved significantly in cancer cell survival in combination with other antitumor agents.SOLUTION: An antitumor agent uses a triazole compound (A) represented by the specified general formula (1) as an HSP90 inhibitor, in combination with an antitumor platinum complex (B). [In the formula, X represents an alkyl group, alkynyl group, or halogen atom Y represents a sulfur atom or oxygen atom m represents an integer between 0 and 4 and A represents an amino group having a substituent.]COPYRIGHT: (C)2014,JPO&INPIT【課題】癌細胞の生存に大きく関与する熱ショックタンパクHSP90を標的とするHSP90阻害剤と、他の抗腫瘍剤とを組み合わせた抗腫瘍剤の提供。【解決手段】HSP90阻害剤として、下記一般式(1)[式中、Xはアルキル基、アルキニル基、またはハロゲン原子、Yは硫黄原子または酸素原子、mは0~4の整数、Aは置換基を有するアミノ基を示す]で表されるトリアゾール化合物(A)と、抗腫瘍性白金錯体(B)を組み合わせた抗腫瘍剤。【選択図】なし
