The present invention provides a composition thatcan effectively improve melasma and a composition that caneffectively reduce skin dullness.The composition for improving melasma comprises apurine nucleic acid-related substance and a pharmaceuticallyor cosmetically acceptable carrier, and exhibits an excellentmelasma improving effect due to the action of the purine nucleicacid-related substance contained. The composition forreducing skin dullness comprises a purine nucleic acid-relatedsubstance and a pharmaceutically or cosmetically acceptablecarrier, and exhibits an excellent effect of reducing skindullness due to the action of the purine nucleic acid-relatedsubstance contained.
