Antibody which has High affinity for soluble and insoluble Tau proteins and modulates the levels of soluble and insoluble Tau； Binding Peptide； Pharmaceutical composition comprising the Peptide or Protein binding an Antibody or polynucleotide； use to treat neurodegenerative disease.
PFEIFER, ANDREA,MUHS, ANDREAS,VAN LEUVEN, FRED,PIHLGREN, MARIA,ADOLFSSON, OSKAR
申请号：
CL2013000951
公开号：
CL2013000951A1
申请日:
2013.04.08
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
The present invention relates to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrially tangles. In particular, the invention relates to antibodies, which specifically recognize and bind to phosphorylated pathological protein tau-conformers and to methods and compositions involving said antibodies for the therapeutic and diagnostic use in the treatment of tauopathies including Alzheimers's Disease (AD).ANTICUERPO QUE PRESENTA ALTA AFINIDAD CON PROTEINAS TAU SOLUBLES E INSOLUBLE Y MODULA LOS NIVELES TAU SOLUBLES E INSOLUBLES； PEPTIDO DE UNION； COMPOSICION FARMACEUTICA QUE COMPRENDE EL PEPTIDO O PROTEINA DE UNION, UN ANTICUERPO O POLINUCLEOTIDO； USO PARA TRATAR ENFERMEDAD NEURODEGENERATIVA.
