METHOD FOR PREDICTION OF CHRONIC SUB-COMPENSATED PLACENTAL INSUFFICIENCY IN THE THIRD TRIMESTER OF PREGNANCY IN WOMEN WITH A CYTOMEGALOVIRUS INFECTION IN THE PAST HISTORY农业专利-农业专业知识服务系统

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METHOD FOR PREDICTION OF CHRONIC SUB-COMPENSATED PLACENTAL INSUFFICIENCY IN THE THIRD TRIMESTER OF PREGNANCY IN WOMEN WITH A CYTOMEGALOVIRUS INFECTION IN THE PAST HISTORY

专利权人:: Federalnoe gosudarstvennoe biudzhetnoe nauchnoe uchrezhdenie «Dalnevostochnyi nauchnyi tsentr fiziologii i patologii dykhaniia»

发明人:: Gorikov Igor Nikolaevich (RU),Гориков Игорь Николаевич (RU),Kolosov Viktor Pavlovich (RU),Колосов Виктор Павлович (RU),Andrievskaia Irina Anatolevna (RU),Андриевская Ирина Анатольевна (RU),Milovanov A

申请号：: RU2020106714

公开号：: RU0002730989C1

申请日:: 2020.02.13

申请国别(地区):: RU

年份:: 2020

代理人:

摘要：: FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to obstetrics, and can be used for prediction of chronic compensated placental insufficiency in the third trimester of pregnancy in women with cytomegalovirus infection in the past history. In women who are seropositive for cytomegalovirus in the second trimester of pregnancy, by ELISA in the blood serum is determined the content of cortisol (A, nmol/l), interleukin-6 – IL-6 (B, pg/ml), interleukin-4 – IL-4 (C, pg/ml). That is followed by predicting the development of chronic sub-compensated placental insufficiency by means of a discriminant equation: D=-0.009×A-0.096×B+0.005×C, where D is a discriminant function with boundary value of -10.86. If D is equal to or greater than the boundary value, the absence of chronic sub-compensated placental insufficiency in the third trimester is predicted. If D is less than the boundary value, development of chronic sub-compensated placental insufficiency in the third trimester is predicted.EFFECT: method provides more accurate prediction of chronic sub-compensated placental insufficiency by determining blood serum seropositive cytomegalovirus in the second trimester of pregnancy with blood serum enzyme immunoassay by analyzing cortisol, IL-6, IL-4, discriminant function D, in relation to which limit value is predicted development of chronic sub-compensated placental insufficiency in the third trimester of pregnancy.1 cl, 2 exИзобретение относится к медицине, а именно к акушерству, и может быть использовано для прогнозирования хронической компенсированной плацентарной недостаточности в третьем триместре беременности у женщин с цитомегаловирусной инфекцией в анамнезе. У серопозитивных по цитомегаловирусу женщин во втором триместре беременности определяют в сыворотке крови иммуноферментным методом анализа содержание кортизола (А, нмоль/л), интерлейкина-6 - IL-6 (В, пг/мл), интерлейкина-4 - IL-4 (С, пг/мл). Затем прогнозируют развитие хронической cубкомпенсированной пл