Shrirang Karve,Zarna Patel,Yi Zhang,Ashish Sarode,Rebecca L. Ball,Frank DeRosa,Michael Heartlein
申请号：
US16553747
公开号：
US20200085745A1
申请日:
2019.08.28
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a solution of pre-formed lipid nanoparticles and mRNA at a low concentration.
