KATHOLIEKE UNIVERSITEIT LEUVEN;LIFE SCIENCES RESEARCH PARTNERS VZW
发明人:
SAINT-REMY, JEAN-MARIE
申请号：
CA2863126
公开号：
CA2863126A1
申请日:
2013.01.30
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention relates to immunogenic peptides comprising a T-cell epitope. Said peptides are modified such that CD4+ T-cell responses are obtainable that are much stronger than the CD4+ T-cell responses obtained with the same peptides not comprising said modification. In particular, the modification is the addition of a cysteine, insertion of a cysteine or mutation into a cysteine of a residue at a position adjacent to but outside the MHC-binding site of the peptide. Further disclosed are the use of such modified peptides in treating, suppressing or preventing diseases such as infectious or allergic diseases and autoimmune diseases, in preventing or suppressing graft rejection, or in the eradication of tumor cells.
