The Regents of the University of California;Buck Institute for Research on Aging;Jagodzinska, Barbara;Campagna, Jesus;Pham, Johnny;Jung, Michael E.
发明人:
申请号：
EP15834442.4
公开号：
EP3183229A4
申请日:
2015.08.19
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
A link between ApoE4 allele and sirtuins expression level is identified that is believed to be associated with elevated risk for the promotion of processing of amyloid precursor protein (APP) by the non-amyloidogenic pathway in a mammal leading to elevated risk for Alzheimer's disease. Compounds are identified that upregulate sirtuins (e.g., SirT1) expression levels and appear to be useful in the treatment and/or prophylaxis of MCI and/or Alzheimer's disease.
