STENSEN, WENCHE,HAUG, BENGT ERIK,REKDAL, OYSTEIN,SVENDSEN, JOHN SIGURD
申请号：
CA2709884
公开号：
CA2709884C
申请日:
2008.12.22
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention relates to a compound of formula (I) AA-AA-AA-X-Y-Zwherein, in any order, 2 of said AA(amino acid) moieties are cationic amino acids and 1 of said AA is an aminoacid with a lipophilic R group, the R group having14-27 non-hydrogen atoms； X is a N atom, which may be substituted by abranched or unbranched C1-C10 alkyl or aryl groupwhich group may incorporate up to 2 heteroatoms selected from N, 0 and S； Yrepresents a group selected from -R a R b-, -R aR b--R b- and -R b-R b-R a wherein R. is C, O, S or N, and R b is C； each of Ra and R b may be substituted by C1-C4 alkyl groups or unsubstituted；and Z is a group comprising 1 to 3 cyclic groups each of 5 or 6 non-hydrogenatoms, 2 or more of the cyclic groups maybe fused and one or more of the cyclic groups may be substituted； the Z moietyincorporates a maximum of 15 non-hydrogenatoms； and wherein the bond between Y and Z is a covalent bond between R a orR b of Y and a non-hydrogen atom of one of thecyclic groups of Z. The invention further relates to formulations containingthese compounds and their uses in therapy, particular-lyas antimicrobial or antitumoural agents.
