CHUNG, Chong-Pyoung,정종평,PARK, Yoon-Jeong,박윤정,RHEE, Sang Hoon,이상훈,LEE, Jue-Yeon,이주연
申请号：
KRKR2011/001611
公开号：
WO2012/033268A1
申请日:
2011.03.09
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
The present invention relates to a peptide having the ability to regenerate bone tissue and for binding to apatite, and more particularly, to a peptide having the ability to regenerate bone tissue, and to a composition containing the peptide for regenerating bone tissue. The peptide has both bone-forming effects and the ability to bind to apatite, by means of binding an amino acid sequence having the ability to regenerate bone tissue to an amino acid sequence having the ability to bind to an apatite. The peptide specifically binds to the inorganic surface of the apatite, and is securely fixed to the apatite surface so as to maintain useful activity for a long period of time, while also exhibiting the effects of bone tissue regeneration. The peptide having the ability to regenerate bone tissue and for binding to apatite according to the present invention can exist in a state in which it is stably bound to an apatite surface such that it can be applied as a bone replacement material for dental or orthopedic applications, and can be applied to metal, natural polymers, and artificial polymers coated with apatite. The peptide can ultimately maximize bone tissue regeneration through the transfer, replication, and accelerated differentiation of cells related to the regeneration of bone tissue. Since the peptide can be maintained in a stable and active state when transplanted in vivo, it can be effectively used for developing technologies for bone tissue regeneration treatments.L'invention concerne un peptide ayant la capacité de régénérer le tissu osseux et de se lier à l'apatite, et plus particulièrement, un peptide ayant la capacité de régénérer le tissu osseux, ainsi qu'une composition contenant ledit peptide pour régénérer le tissu osseux. Ledit peptide à la fois stimule l'ostéoformation et se lie à l'apatite, en liant une séquence d'acides aminés capable de régénérer le tissu osseux à une séquence d'acides aminés capable de se lier à une apatite. Ledit peptide se lie
