INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
发明人:
DIMARCHI, RICHARD D.,KOU, BINBIN
申请号：
PE0012382011
公开号：
PE03322012A1
申请日:
2009.12.18
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Structure refers to a prodrug of a - B - Q, where q is the superfamila Peptide glucagon hydroxy acid is an amino acid or a b is an amino acid n - linked to q rented through a link between amide and Amide - B Q, where a, B, or amino acid of q which is attached to is a to B Minoacido uncoded - B has the structure (i) wherein: R1, R2, R4 and R8 are each h,Alquenilo C18 alkyl C1, C2 (C1 - C18 alkyl C18 (C1) Oh, SH - C18 alkyl (alkyl), C2 - C3) Sch3, among others R3 is C1 - C18 alkyl (alkyl C1 - C18, NH2 (C0) alkyl, cycloalkyl - C6 C3 - C4), between others. In addition to such a Pharmaceutical composition. The prodrug is useful in the treatment of hyperglycaemia, Treatment or prevention of hypoglycemia, Appetite suppressionSE REFIERE A UN PROFARMACO DE ESTRUCTURA A-B-Q DONDE: Q ES PEPTIDO DE LA SUPERFAMILA DE GLUCAGON A ES UN AMINOACIDO O UN HIDROXIACIDO B ES UN AMINOACIDO N-ALQUILADO LIGADO A Q POR MEDIO DE UN ENLACE DE AMIDA ENTRE A-B Y AMIDA DE Q, EN DONDE A, B O EL AMINOACIDO DE Q AL CUAL ESTA UNIDO A-B ES UN AMINOACIDO NO CODIFICADO A-B PRESENTA LA ESTRUCTURA (I) DONDE: R1, R2, R4 Y R8 SON CADA UNO H, ALQUILO C1-C18, ALQUENILO C2-C18, (ALQUILO C1-C18)OH, (ALQUILO C1-C18)SH, (ALQUILO C2-C3)SCH3, ENTRE OTROS R3 ES ALQUILO C1-C18, (ALQUILO C1-C18)NH2, (ALQUILO C0-C4)CICLOALQUILO C3-C6, ENTRE OTROS. REFERIDA ADEMAS A UNA COMPOSCION FARMACEUTICA. DICHO PROFARMACO ES UTIL EN EL TRATAMIENTO DE HIPERGLUCEMIA, TRATAMIENTO O PREVENCION DE LA HIPOGLUCEMIA, SUPRESION DEL APETITO
