HUANGSHU LEI,YOUNG SHIN CHO,MARK G. PALERMO,JULIAN ROY LEVELL,BAKARY TOURE,FAN BARRY - YANG,THOMAS CAFERRO,FRANCOIS LENOIR,GANG LIU,MICHAEL DAVID SHULTZ,TROY D. SMITH,ABRAN Q. COSTALES,KEITH BRUCE PFI
申请号：
ARP120103605
公开号：
AR088175A1
申请日:
2012.09.27
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
1. Characteristic 1: a formula compound (1), wherein: each R 1 and R 2 is independently hydrogen, deuterium, halogen, hydroxyl, nh483222；optionally substituted aryl, heteroaryl, or C₁₋₄ alkyl, wherein said C₁₋₄ alkyl is optionally substituted by one to three substituents each independently selected from the group consisting of: halo, hydroxyl, and NH₂；R³ᵃ is hydrogen, deuterium, C₁₋₆ alkyl,phenyl, or benzyl and R³ᵇ is hydrogen, deuterium, or C₁₋₆ alkyl；O R3 74911 and R3 74955 combine to form a selectively replaceable 3-7 cyclopropyl ring or a selectively replaceable 4-7 heterocyclic ring, The cyclopropyl ring and the heterocyclic ring are each replaced by one or two independently selected groups consisting of halo, hydroxyl, oxygen and nh832222；and C₁₋₃ alkyl；R⁴ᵃ is hydrogen, C₁₋₆ alkyl,Alternative benzene, or alternative benzene, alternative isopropene, or methylenedibenzene, wherein benzene, benzene, and isopropene rings may be replaced by one to three independent substitutes of halogenated, hydroxy, cyanogen, nitro, and alcoxyl groups. C83218331；Halogenated tar c83218323；C₁₋₃ haloalkoxy,1. Lease land No. c833218331 and 832626；C₃₋₆ cycloalkyl,5-6 members heteromorphic, 5-6 members heteromorphic phenyl, coor74955,SO₂Rᵇ,NHC (O) Re. Nr74955 and r74955 and r8308； 74959 is hydrogen, deuterium or c83218d83223；O r8308；； 74919 and r8308；； 74955 combine to form a ring armour ring consisting of 3-7 optional replacement members or 4-7 optional replacement members, Among them, cyclopropyl ring and heterocyclic ring can be replaced by one or two individually selected group substitutes consisting of halo, hydroxyl, oxo and nh-832222；and C₁₋₃ alkyl,But the conditions are: there is only one ring composed of R3 7491 and R3 74955 and r8308； 7491 and r8308； 749595； r8309； 74919 is hydrogen or deuterium； r8309； 7495s is hydrogen, deuterium, methyl, ethyl, cd83223；CF8323,CH₂F, or CHF₂ and R⁶ is optionally substituted C₁₋₆ alkyl,optionally substituted aryl, heteroaryl, optionally subst
