The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof)； methods of administering chimeric and hybrid polypeptides comprising Factor VIII； chimeric and hybrid polypeptides comprising Factor VIII； polynucleotides encoding such chimeric and hybrid polypeptides； cells comprising such polynucleotides； and methods of producing such chimeric and hybrid polypeptides using such cells.
