A method of treatment to reduce the frequency of migraine headaches and lessen the severity of associated symptoms by a daily intake of a combination of dietary supplements, namely riboflavin, magnesium, vitamin B12 and coenzyme Q10. The preferred daily dosage of the invention is riboflavin, 50 mg magnesium, 400 mg as elemental magnesium vitamin B12, 1000 μg and coenzyme Q10, 50 mg. The magnesium is preferably in the form of magnesium oxide. The dietary supplements are generally recognized as safe for human consumption. The four dietary supplements synergistically act together at the preferred dosage ranges and are uniquely suited for preventing and reducing the occurrence of migraine headaches and associated symptoms.