A baby bottle cover with tactile stimulation design is used to cover a baby bottle, the baby bottle includes a silicone case with an inner surface and an outer surface, and the inner surface defines an inner surface which conforms with the shape of the baby bottle. A plurality of the conical portions is integrally formed on the outer surface of the silicone case. When the baby holds the bottle, the soft conical portions formed on the outer surface of the baby bottle cover come into contact with the babys hands to promote the development of babys tactile sense.