PONS, JAUME,DEMING, LAURA,GOODMAN, COREY,SIM, BANG JANET,KAUDER, STEVEN ELLIOT,WAN, HONG,KUO, TRACY CHIA-CHIEN
申请号：
CA2993835
公开号：
CA2993835A1
申请日:
2016.08.05
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present disclosure features signal-regulatory protein a (SIRP-a) polypeptides and constructs that are useful, e.g., to target a cell (e.g., a cancer cell or a cell of the immune system), to increase phagocytosis of the target cell, to eliminate immune cells such as regulatory T-cells, to kill cancer cells, to treat a disease (e.g., cancer) in a subject, or any combinations thereof. The SIRP-a constructs include a high affinity SIRP-a D1 domain or variant thereof that binds CD47 with higher affinity than a wild-type SIRP-a. The SIRP-a polypeptides or constructs include a SIRP-a D1 variant fused to an Fc domain monomer, a human serum albumin (HSA), an albumin-binding peptide, or a polyethylene glycol (PEG) polymer. Compositions provided herein include (i) a polypeptide including a signal-regulatory protein a (SIRP- a) D1 variant and (ii) an antibody.
