A medication treatment kit and method for treating difficult-to-manage disease that require medication be administered in a particular order for effective treatment where the treatment kit has a container, a first-line treatment medication within the container, and a second-line treatment medication within the container wherein the container is configured to ensure the first-line treatment medication and the second-line treatment medication are administered in proper order where there are no other medications located side-by-side relative to the first-line treatment medication and where only the first-line treatment medication is initially presented and where the first-line treatment medication and the second-line treatment medication are medications to treat a patient having a difficult-to-manage disease.