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PROCEDES DE PRECONTRAINTE ET DE COIFFAGE DE TISSU BIOPROTHETIQUE
专利权人:
EDWARDS LIFESCIENCES CORPORATION
发明人:
DAVIDSON, JIM,DOVE, JEFF,DOBLER, DARIN
申请号:
CA2688404
公开号:
CA2688404C
申请日:
2008.06.10
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification is disclosed. The method includes preconditioning, pre-stressing, or pre-damaging fixed bioprosthetic tissue in a manner that mimics the damage associated with post- implant use, while, and/or subsequently applying a calcification mitigant such as a capping agent or a linking agent to the damaged tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the damage process (service stress) and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. The linking agent will act as an elastic reinforcement or shock- absorbing spring element in the tissue structure at the site of damage from the pre-stressing. In one method, tissue leaflets in assembled bioprosthetic heart valves are preconditioned by simulating actual flow conditions for a predetermined number of cycles, during or after which the valve is exposed to the capping agent.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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