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APPLICATION THÉRAPEUTIQUE D'INHIBITEURS DE SÉRINE PROTÉASE DE TYPE KAZAL
专利权人:
CSL BEHRING GMBH
发明人:
申请号:
EP08707646.9
公开号:
EP2109457B1
申请日:
2008.02.11
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
The subject of the present invention is, in the most general aspect, the therapeutic application of the Kazal-type serine protease inhibitor Infestin or domains thereof or modified Kazal-type serine protease inhibitors based on Infestin homologs, which prevent the formation and/or stabilization of three-dimensional arterial or venous thrombi by interfering with proteins involved in activation of the so-called intrinsic coagulation pathway. In particular the present invention relates to the use of said Kazal-type serine protease inhibitors or fragments thereof or modified Kazal-type serine protease inhibitors, in the treatment or prophylaxis of a condition or disorder related to arterial thrombus formation, i. e. stroke or myocardial infarction, inflammation, complement activation, fibrinolysis, angiogenesis and/or diseases linked to pathological kinin formation such as hypotonic shock, edema including hereditary angioedema, bacterial infections, arthritis, pancreatitis, or articular gout, Disseminated Intravasal Coagulation (DIC) and sepsis.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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