The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).本揭露提供具有式(I)之化合物其中A2、A3、A4、A6、A7、A8、A15、RA、R5、R9、R10A、R10B、R11、R12、R13、R14、R16、W、X、和Y具有本說明書中定義的任何值,並且提供了該等化合物的藥學上可接受的鹽,該等化合物和鹽可用作對疾病和病症進行治療的藥劑,所述疾病和病症包括病症。還提供了包含具有式(I)之化合物的藥物組成物。