ELIAS KATHLEEN ANN,LANDES GREGORY,SINGH SHWETA,KORVER WOUTER,DRAKE ANDREW WALLING,HAAK-FRENDSCHO MARY,SNELL GYORGY PAL,BHASKAR VINAY
申请号：
NZ70584811
公开号：
NZ705848A
申请日:
2011.12.30
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed is an isolated antibody which specifically binds human CD38 (SEQ ID NO: 1, as defined in the complete specification) and cynomolgus CD38 (SEQ ID NO: 2, as defined in the complete specification) comprising: a) a heavy chain variable region comprising: i) a first CDR comprising SEQ ID NO: 13 (GFTFNNYD) ii) a second CDR comprising SEQ ID NO: 14 (ISYDGSDK) iii) a third CDR comprising SEQ ID NO: 15 (ARVYYYGFSGPSMDV) and b) a light chain variable region comprising: i) a first CDR comprising SEQ ID NO: 16 (NSNIGSNT) ii) a second CDR comprising SEQ ID NO: 17 (SDS) iii) a third CDR comprising SEQ ID NO: 18 (QSYDSSLSGSR). Also disclosed is the use of said antibody in the manufacture of a medicament for the treatment of an auto immune disease.
