Provided is an omnidirectional scientific toothbrush comprising a brush handle (2) and a brush head (3), wherein the brush head (3) has a U-shaped structure; a central gear set (309), a tooth outer side brush roller (302), a tooth inner side brush roller (307) and a tooth end surface brush roller (303) are installed in the brush head (3); the brush handle (2) is provided with a power output mechanism driven by a micro motor (218), wherein the power output mechanism drives the central gear set (309) to rotate, so that the tooth outer side brush roller (302) and the tooth inner side brush roller (307) at both sides of the same tooth are rotated in an opposite direction and both rotation directions are from the tooth root to the tooth end, and the rotational action of the tooth end surface brush roller (303) can simultaneously scrub end surfaces of the upper and lower rows of teeth (6, 7) in the oral cavity along the tooth gap. When brushing the teeth, there is no need for the user to manually control the brush head (3) of the toothbrush to move, that is, a tooth full-mouth cleaning operation can be automatically completed, thereby greatly improving the quality and efficiency of brush cleaning, greatly reducing the time cost and energy consumption of brushing, and easily achieving an intelligent and automatic brushing mode.