ITO, KAZUHIRO,KING-UNDERWOOD, JOHN,ONIONS, STUART THOMAS,LONGSHAW, ALISTAIR IAN,BROECKX, RUDY,FILLIERS, WALTER,COPMANS, ALEX,CHARRON, CATHERINE ELISABETH
申请号：
PE2014000468
公开号：
PE20142355A1
申请日:
2012.10.03
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
As for urea (I) of compound 1 - (3-terc-butil-1-p-tolil-1h-pirazol-5-il) - 3 - (4 - (2 - (phenyl) pirimidin-4-iloxi) naftelen-1-il),As a two water free base of crystal form, it is composed of diffraction peaks of 10.3, 15.2, 17.5, 23.1, 24.6, 26.7 and 27.4 degree 2-theta selected X-ray powder. A pharmaceutical composer was also mentioned This compound is an inhibitor of p38 myth induced protease, which is useful in the treatment of inflammation, including lung inflammation such as asthma and COPD.REFERIDA AL COMPUESTO 1-(3-TERC-BUTIL-1-p-TOLIL-1H-PIRAZOL-5-IL)-3-(4-(2-(FENILAMINO)PIRIMIDIN-4-ILOXI)NAFTALEN-1-IL)UREA DE FORMULA (I), COMO BASE LIBRE ANHIDRA EN FORMA CRISTALINA QUE PRESENTA UN PATRON DE PICOS DE DIFRACCION DE POLVOS DE RAYOS X SELECCIONADO DE 10,3, 15,2, 17,5, 23,1, 24,6, 26,7 Y 27,4 GRADOS 2-THETA. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN INHIBIDOR DE LA FAMILIA DE ENZIMAS CINASAS DE LA PROTEINA ACTIVADA POR EL MITOGENO p38 Y ES UTIL EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS, INCLUYENDO ENFERMEDADES INFLAMATORIAS DEL PULMON TALES COMO ASMA Y COPD
