Deepa M. Deshpande;Dorothy Pui-Yuk Ko;Douglas A. Kerr
发明人:
Deepa M. Deshpande,Douglas A. Kerr,Dorothy Pui-Yuk Ko
申请号：
US12093452
公开号：
US08986676B2
申请日:
2006.11.10
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides methods for inducing differentiation of an embryonic stem cell into a motor neuron using a motoneuronotrophic factor (MNTF) or its peptide analogs. The present invention further provides a method for isolating a population of stem cell derived motor neurons and a population of cells comprising the differentiated neural cells. Additionally, the present invention is directed to a method of enhancing the survival of the differentiated neural cells in long term cell cultures. Finally, the present invention provides compositions containing MNTF or its peptide analogs for therapeutic use in conjunction with stem cells.
