Method determines that at least one parameter is performed for injection process, it may include that the fluid for injecting test comparison degree enhancing pill has contrast-enhancing agents with image forming program, region of interest and imaging system are scanned as testing bolus flow therethrough from the time of contrast is wherein obtained for each interested enhancement curve, extract time of at least one discrete data point from each contrast enhancement curve, so that each discrete data point constitutes a pair of of measurement contrast time enhancement curve and is accordingly lower, substitute into the time that model discrete data point extracts, to obtain the value from the estimation physiologic variables of contrast intensifications curve, and at least one parameter is determined using the estimation, the model is performed by injection process, in conjunction with imaging process.