PROBLEM TO BE SOLVED: To provide anti-RANKL antibodies and methods of use.SOLUTION: The present invention provides an isolated antibody, or an antigen-binding fragment thereof, that binds to RANKL, comprising (i) a heavy chain variable region comprising the VHCDR1 region and VHCDR2 region and VHCDR3 region which are represented by a particular sequence, and (ii) a light chain variable region comprising VLCDR1 region and VLCDR2 region and VLCDR3 region which are represented by a particular sequence； or a variant of antibody, or an antigen-binding fragment thereof, comprising heavy and light chain variable regions identical to the heavy and light chain variable regions of (i) and (ii) except for up to 8 amino acid substitutions in the CDR regions.SELECTED DRAWING: None【課題】抗ＲＡＮＫＬ抗体及び使用方法の提供。【解決手段】（ｉ）特定の配列で表される、ＶＨＣＤＲ１領域とＶＨＣＤＲ２領域とＶＨＣＤＲ３領域とを含む重鎖可変領域と、（ｉｉ）特定の配列で表される、ＶＬＣＤＲ１領域とＶＬＣＤＲ２領域とＶＬＣＤＲ３領域とを含む軽鎖可変領域とを含む、ＲＡＮＫＬに結合する単離抗体又はその抗原結合フラグメント、あるいはＣＤＲ領域における８個までのアミノ酸置換を除いて、（ｉ）及び（ｉｉ）の重鎖可変領域及び軽鎖可変領域と同一の重鎖可変領域及び軽鎖可変領域を含む抗体の改変体、又はその抗原結合フラグメント。【選択図】なし
